The Easiest Way To Barring Skin Cancer

 

A recent study found, the consumption of aspirin and anti-inflammatory medications such as ibuprofen and naproxen can prevent some types of turns out to be skin cancer. Researchers find Denmark, consume regularly painkillers such as aspirin can reduce about 15 percent risk of developing skin cancer, especially melanoma deadliest types such as.

The team examined the 200 thousand animals as an experiment, 18 thousand of whom diagnosed exposed one of of three types of skin cancer are dangerous. Three types of skin cancer are dangerous among them basal cell carcinoma, squamous cell carcinoma and melanoma malignant hypertension.

As a result, those who get Nonsteroidal Antiinflammatory Drugs (NSAIDs) or drug-drug anti-inflammatory for the heart or less risky exposed arthtitis skin cancer. "We expect the effect of NSAIDs for protection against skin cancer, can inspire further research," said researchers from Aarhus University Hospital in Denmark, Sigrun Alba Johannesdottir.

Even though the study showed can inhibit the growth of NSAIDs pre skin cancer lesions on animals, not yet seen its effects in humans. Researchers say the need for further research to confirm the findings in humans.

Treatment of Skin Cancer by Dynamic Phototherapy (PDT)

Dynamic photo-therapy uses a photosynthesizing substance that is applied to the skin for a few hours before his exposure to a specific light.

Dynamic photo-therapy uses a photosynthesizing substance (causing a tissue susceptibility to some lights) that is applied on the skin for a few hours before his exposure to a specific light (light blue or red).

The substance is applied to the skin as a liquid or cream that contains (5-ALA-HCL) aminolevulinic acid and the methyl aminolevulinate (MAL). These photo-sensitizers is specifically absorbed by the diseased tissues, and sebaceous glands.

The Red or blue light exposure is achieved with a special lamp that active substance that has penetrated the tissues. Activation of photosynthesizing substance causes the specific destruction of tissues which have absorbed it.

The Galderma laboratory markets Metvixia cream France, its use is indicated for the treatment of Actinic Keratoses (precancerous Keratoses), superficial basal cell carcinomas face and the Bowen disease (Intraepidermal squamous cell carcinoma). Metvixia  cream is applied to the area was treated for three hours before lighting lights LED red (Aktilite). Metvixia treatment protocol is detailed on a separate sheet. Metvixia ® is available now in France. The essential interest of dynamic phototherapy with Metvixia (MAL - PDT) is the treatment of cancer of the skin, it allows eliminating virtually without scar of precancerous lesions of the skin and certain cancers. This technique also allows to simultaneously process several lesions. One or several treatments may be necessary.

The DUSA laboratory markets the Levulan Kerastic in the United States and the Canada, it is a liquid applied to the area to treat for 12 to 16 hours before its activation by light blue (BLU - U). Dynamic phototherapy with 5 - ALA (ALA - PDT) is also used to destroy Keratoses Actinic but also in the treatment of acne and the field of aesthetics (treatment of brown spots and wrinkles). Levulan kerastick is not indicated for the treatment of skin cancer.

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Melanoma Diagnosis and Its More Effective Therapies

The fight against melanoma, skin cancer is particularly aggressive, now has new allies: early diagnosis that relies on new tools and a therapy that is enriched by innovative drugs that have been shown to stop the evolution of the disease even when it is in an advanced stage. On the occasion of the Congress of Italian melanoma Inter-group (Imi) presented the novelties, including Alexander Testori, outgoing President of Imi, speaks to Dica33.

 

Dr. Testori, starting with the diagnosis: what is new?

About two years ago has been introduced which allows confocal microscopic analysis of pigmented lesions without having to remove. The laser draws the profile of cells up to a thickness of 250 microns, i.e. the thickness of the epidermis. Is similar to a histological examination but requires the removal, and then allows you to select a more sophisticated who submit removal: intervene, for example, on early stage melanomas, or not, if the lesion is not suspected. It is a very important innovation to find out what are the most serious patients to follow

Then all suspects must be analyzed in this way?

This method is suitable if there are few injuries or to examine those previously selected with dermatology, another that detects among many, sometimes there are up to 300 in atypical in the same patient, to be sent to surgery. Confocal with the selection becomes even more pressing and undergoes surgery only those most at risk. Typically, when in many investigations are always a mapping of in, that is a digital recording of all those that the dermatologist sees. We must not forget that early diagnosis with melanoma is simple because just look at the patient.

On the front of the treatment have been made strides?

The biggest successes have always obtained by surgery, which remains the central pillar of the cure, but there are new drugs that are modifying the disease course with the goal is to make it chronic, i.e. not to advance. The two drugs are immutability and deafening. The first acts on the immune system and binds a receptor of T cells, blocking component that prevents the immune response. In essence, a kind of brake on the immune response and the patient with melanoma draws benefits with an increase in survival. Vemurafenib has another mechanism, as it inhibits the B-Raf gene that is altered in 60% of patients and is used only in these cases.

That results are obtained with these new drugs?

Both were designed with patients with metastasis with advanced disease. In recent, then trials rather with data collected within 2-3 years, it has been observed an increase in survival of 30%, this means that if patients lived an average of six months with the treatment allusiveness survival without progression of disease until 9-11 months. It is a matter of global media, which is played on large numbers, and this means that some patients could live much longer, even for 20 years without disease progression. Now the intention is to experience the two drugs in combination, with the assumption that their action mechanisms against cancer cells to be compounded.

Drugs are available in Italy?

No, have not yet been approved, although in the United States and Europe the approval procedure has already passed some passages. But it remains the problem of high costs which will have to face when they enter the market. Just to get an idea: four vials of ipilimumab, administered once every three weeks cost 84mila euro.

Skin Cancer Symptoms and Its Treatment

Skin cancer-Definition

Malignant tumors caused by uncontrolled growth of several types of cells of the epidermis, the top layer of the skin. Skin tumors can take origin from keratinocytes (epithelial cells) or by melanocytes (the cells that are responsible for producing melanin, which gives rise to in aggregate). In the first case are called basal cell carcinomas (a departure from the deepest layer of the epidermis) or spinocellulari (for more superficial cells source). A malignant tumor of melanocytes is called melanoma.

Skin cancer-causes

The main risk factor for the development of skin cancers, particularly with regard to carcinomas, is chronic exposure to sunlight, specifically ultraviolet rays. For this reason, the parts of the body most affected are those most exposed to the Sun: the face, ears, neck, scalp, shoulders, and back. For melanomas, a predisposing factor is represented by the presence of moles, especially if many (more than 50), large and irregular edges.

Skin cancer-symptoms

Multiple basal cell carcinomas occur in the form of small nodules of pearly appearance slowly increasing in size and are often hard to the touch. Carcinoma spinocellulare initially appears as a small red and scaly area which gradually enlarges and can take on the appearance of a wart. Both of these forms have a reduced tendency to spread into the body and are generally not dangerous. The melanomas originate from within, which undergo changes visible to the naked eye (swollen, loss of regularity of edges and shape, color change, which may be black, brownish, reddish, bluish or even pearly whites). The Melanoma can grow rapidly and spread in the body through movement.

Skin Cancer-Diagnosis

Skin tumors are diagnosed by a specialist dermatologist following examination, conducted with the help of epiluminescence examinations, namely the observation through a lens polarized light, the deeper layers of the skin. Certain diagnosis and definition of the type of cancer require performing a biopsy.

Skin cancer-Cure

The main treatment of skin cancers is the surgical removal of the affected tissues. In the case of multiple basal cell carcinomas or spinocellulari can be used techniques of microsurgery, laser surgery or with liquid nitrogen. For melanoma, surgery is more extensive and also includes the removal of surrounding lymph nodes. In unresectable cases, chemotherapy is used. Are also in experimentation, with encouraging results, forms of immunotherapy and antitumor vaccination.

Skin cancers-alternative Cures

There are herbal remedies can stimulate the immune system features, as well as homeopathy, acupuncture and aromatherapy have been used for the treatment of side effects. All these approaches are complementary and should be carried out under the supervision of your physician.

Skin cancer-Nutrition

Follow a diet low in fat and rich in antioxidants (vitamins A, C and E, Coenzyme Q10, beta-carotene, green tea and ginger) may reduce the risk of skin cancers.

How to Prevent the Development of Skin Cancer Squamous Cell Carcinoma

An extraordinary step forward in understanding what stops the development of one of the most common skin cancer could help to create new treatments available to patients within the next 5 years. In a study recently published in the journal Cancer Cell, an international team of scientists led by Australian researchers has discovered a gene that helps protect the body from squamous cell carcinoma (SCC) of the skin.

 

The Australian Cancer Council estimates that two in three Australians will be diagnosed with skin cancer before 70 years to accomplish, with squamous cell carcinoma as the most common type. Until now, the genetic basis of cancer had not been fully understood, and the only treatment option has been surgical removal.

However, experts have found that there is a protective gene that is abnormally absent in people with this carcinoma. While researchers originally congregated on skin cancer, they saw that this gene is also absent in SCC arising in other tissues, such as the head and neck, frequently associated with a poor prognosis. As a result, scientists have shown that the absence of a protective gene in particular cancel signal that prevents skin cells continue to grow.

The fact that we have identified this gene provides a clear direction for the development of strategies for prevention, how to cure cancer, in the near future. Indeed, this study suggests that certain drugs currently used in clinical trials may be effective even on this carcinoma. The same thing happens with the prevention; There are already strategies where it increases the expression of a gene to protect a fabric. In this case, use molecules to increase the expression of this gene can prevent the development of skin cancer, for example in the form of sunscreen.

In conclusion, the benefits of this study may be the hand of patients in less than 5 years.